Ispinesib
SIGMA/SML2869 - ≥98% (HPLC)
Synonym: (R)
CAS Number: 336113-53-2
Empirical Formula (Hill Notation): C30H33ClN4O2
Molecular Weight: 517.06
MDL Number: MFCD22628831
Linear Formula: C30H33ClN4O2
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
optical activity | [α]/D +315 to +375°, c = 0.5 in chloroform-d |
Quality Level | 100 ![]() |
solubility | DMSO: 2 mg/mL, clear |
storage temp. | 2-8°C |
Biochem/physiol Actions: | Ispinesib (SB-715992) is a potent and highly selective kinesin spindle protein (KSP, KIF11, EG5) allosteric inhibtor that specifically inhibits microtubule (MT)-stimulated ATPase activity of KSP (Ki = 1.7 nM; 5 μM MT, 500 μM ATP, 0.75 nM human KSP), but not ubiquitous kinesin heavy chain KHC, neuronal kinesin KIF1A, or mitotic kinesins CENP-E, RabK6, MCAK, MKLP1. Ispinesib exhibits anti-cancer efficacy in cultures (GI50 = 45 nM/BT-474 & 19 nM/MDA-MB-468) and in cancer xenograft models in vivo (8 or 10 mg/kg q4d×3 ip. mice with MCF-7, HCC-1954, KPL4, BT-474 xenografts). |
Symbol | ![]() ![]() |
Signal word | Danger |
Hazard statements | H300 + H330 - H341 |
Precautionary statements | P202 - P260 - P264 - P270 - P271 - P304 + P340 + P310 |
WGK Germany | WGK 3 |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |