Synonym: (1R,3S)-3-Propionylaminocyclopentanecarboxylic acid N-[4-(benzoxazol-2-yl)phenyl]-N-methylamide; (1R,3S)-N-[4-(2-Benzoxazolyl)phenyl]-N-methyl-3-[(1-oxopropyl)amino]cyclopentanecarboxamide; BI99179
CAS Number: 1291779-76-4
Empirical Formula (Hill Notation): C23H25N3O3
Molecular Weight: 391.46
MDL Number: MFCD25976795
Linear Formula: C23H25N3O3
Product Type: Chemical
assay |
≥98% (HPLC) |
color |
white to beige |
form |
powder |
Quality Level |
100 ![External link](https://krackeler.com/images/sigma/ext-link.gif) |
SMILES string |
CCC(N[C@H]1CC[C@@H](C(N(C)C2=CC=C(C=C2)C3=NC4=C(O3)C=CC=C4)=O)C1)=O |
solubility |
DMSO: 2 mg/mL, clear |
storage temp. |
−20°C |
Biochem/physiol Actions: |
BI 99179 is a non-cytotoxic (by LDH release; 30 μM, U937) orally available, brain-penetrant, highly potent and selective fatty acid synthase (FAS, FASN) inhibitor (IC50 = 79 nM by cell-free human FAS assay) with little or no inhibitory potency toward a panel of 30 receptors & channels (<20% inhibition at 10 μM) and human CYP450 isoenzymes (1A2/2C9/2C19/2D6/3A4 IC50 >10 μM). BI 99179 inhibits cellular FAS activity in vitro (IC50 = 180 nM/human H1975, 600 nM/murine hypothalamic N-42 cells) and increases hypothalamic [malonyl-CoA] in rats in vivo (2 h post 10 mg/kg or 2-24 hr post 100 mg/kg p.o.). Note: adverse effects in rats are reported at day 4 (30 mg/kg) and day 9 (3 mg/kg). |
Purity |
≥98% (HPLC) |
Storage Temp. |
−20°C |
UNSPSC |
12352200 |