Synonym: ((2R,3S,4R,5R)-3,4-Dihydroxy-5-(4-(hydroxyamino)-2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate; (oh)4Cyd lester; 4-N-HO-Cyd ester; BHC ester; EIDD 1931 5′-isopropylester; EIDD 1931 prodrug; EIDD 2801; EIDD-1931 5′-isopropylester; EIDD-1931 prodrug; EIDD1931 5′-isopropylester; EIDD1931 prodrug; EIDD2801; N4-Hydroxycytidine 5′-isopropylester; N4-OHcyd ester; N4OHcyd ester; NHC ester; beta-D-N4-Hydroxycytidine 5′-isopropylester
CAS Number: 2349386-89-4
Empirical Formula (Hill Notation): C13H19N3O7
Molecular Weight: 329.31
Linear Formula: C13H19N3O7
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to beige |
| form |
powder |
| Quality Level |
100  |
| solubility |
DMSO: 2 mg/mL, clear |
| storage temp. |
−20°C |
| Biochem/physiol Actions: |
EIDD-2801 is an orally active, 5′-isopropylester prodrug form of the antiviral ribonucleoside analog N4-hydroxycytidine (NHC, EIDD-1931) with known anti-viral activity against SARS-CoV, SARS-CoV-2, RSV, influenza A & B (IAV & IBV), HCV, pestivirus, bovine viral diarrhoea virus (BVDV), Ebola (EBOV), Chikungunya (CHIKV), venezuelan equine encephalitis (VEEV). EIDD-2801 is efficiently hydrolyzed to NHC in vivo, being more orally bioavailable than NHC in nonhuman primates and ferrets, while maintaining similar oral bioavailability as NHC in mice. EIDD-2801 displays in vivo efficacy against pandemic and seasonal IAV strains in ferrets (lowest ED = 2.3 and 7 mg/kg b.i.d. p.o., respectively). |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
12352200 |
