Y-39983 dihydrochloride
SIGMA/SML2920 - ≥98% (HPLC)
Synonym: 4-
CAS Number: 173897-44-4
Empirical Formula (Hill Notation): C16H16N4O · 2HCl
Molecular Weight: 353.25
MDL Number: MFCD00945328
Linear Formula: C16H16N4O · 2HCl
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
optical activity | [α]/D +5 to +9°, c = 1 in methanol |
Quality Level | 100 ![]() |
SMILES string | N[C@@H](C1=CC=C(C(NC2=CC= |
solubility | DMSO: 2 mg/mL, clear |
storage temp. | −20°C |
Biochem/physiol Actions: | Y-39983 is a potent and selective Rho-kinase (ROCK) inhibitor (IC50s = 3.6 nM). Y-39983 is 10 fold more potent in promoting the outgrowth of neurites in cultured retinal slices and axonal regeneration in crushed optic nerve models than Y-27632. Y-39983 act also as an activator of the neuroprotective Parkin-mediated mitophagy pathway. |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |