LH1307
SIGMA/SML2930 - ≥97% (HPLC)
Synonym: 2,2′-Dimethyl-3,3′-bis[2-methyl-4-(2-acetamidoethylamino)-methyl-5-(3-cyanopyridin-5-yl-methoxy)phenoxymethyl]-1,1′-biphenyl; LH 1307; LH-1307; N,N′-(2,2′-(4,4′-(2,2′-Dimethylbiphenyl-3,3′-diyl)bis(methylene)bis(oxy)bis(2-((5-cyanopyridin-3-yl)methoxy)-5-methyl-4,1-phenylene))bis(methylene)bis(azanediyl)bis(ethane-2,1-diyl))diacetamide
CAS Number: 2375720-38-8
Empirical Formula (Hill Notation): C54H58N8O6
Molecular Weight: 915.09
Linear Formula: C54H58N8O6
Product Type: Chemical
assay | ≥97% (HPLC) |
color | white to beige |
form | powder |
Quality Level | 100 ![]() |
SMILES string | N#CC1=CC(COC2=C(C=C(C(OCC |
solubility | DMSO: 2 mg/mL, clear |
storage condition | room temperature |
storage temp. | 2-8°C |
Biochem/physiol Actions: | LH1307 is a potent programmed cell death-1/programmed death-ligand 1 (PD-1 (CD279, PDCD1)/PD-L1 (B7-H1, PDCD1-L1)) protein-protein interaction (PPI) inhibitor (IC50 = 3 nM by HTRF assay) that induces symmetrically arranged PD-L1 homodimer formation by targeting PD-L1 at the PD-1 binding site. LH1307 effectively blocks cell surface PD-1/PD-L1 interaction between PD-1-expressing Jurkat cells and co-cultured PD-L1-expressing U2OS cells (SHP-1 recruitment IC50 = 79 nM) or co-cultured PD-L1-expressing aAPC/CHO-K1 cells (NFAT signaling restoration EC50 = 763 nM). |
Purity | ≥97% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |