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GSK264220A

SIGMA/SML2931 - ≥98% (HPLC)

Synonym: 1-[[5-Methyl-4-[[(phenylamino)carbonyl]amino]-2-furanyl]sulfonyl]piperidine; GSK 264220A; N-[2-Methyl-5-(1-piperidinylsulfonyl)-3-furanyl]-N′-phenylurea

CAS Number: 685506-42-7
Empirical Formula (Hill Notation): C17H21N3O4S
Molecular Weight: 363.43
MDL Number: MFCD02679009
Linear Formula: C17H21N3O4S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML2931-5MG 5 mg
 $85.30
1/EA		 Add To Favorites
45-SML2931-25MG 25 mg
 $430.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
Quality Level 100 
solubility DMSO: 2 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: GSK264220A is a potent, active site-targeting, covalent inhibitor against endothelial lipase (EL or LIPG; IC50 = 130 nM) and lipoprotein lipase (LPL or LIPD; IC50 = 100 nM). GSK264220A reduces NeuT expression - or CoCl2 treatment-induced intracellular triacylglycerol & lipid droplets (TAG & LD) increase in MCF-7 (16 & 32 nM) and suppresses LPL-depenent melanoma survival (by ~50% at 18.75 μM; WM852, WM1361). When applied in mice in vivo (30 mg/kg ip.), GSK264220A21 enhances lipid nanoparticles-mediated siRNAs delivery & gene-silencing efficacy.
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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