SGC-CK2-1
SIGMA/SML2951 - ≥98% (HPLC)
Synonym: N-
CAS Number: 2470424-39-4
Empirical Formula (Hill Notation): C20H21N7O
Molecular Weight: 375.43
Linear Formula: C20H21N7O
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
Quality Level | 100 ![]() |
solubility | DMSO: 2 mg/mL, clear |
storage temp. | 2-8°C |
Biochem/physiol Actions: | SGC-CK2-1 is a potent and highly selective casein 2 (CK2, CKII) inhibitor (CK2α/CK2α’ IC50 = 4.2/2.3 nM by cell-free enzyme assay; DYRK2 IC50 = 440 nM, IC50≥3.4 μM against 465 other kinases). Unlike less specific CK2 inhibitors, SGC-CK2-1 shows no antiproliferation activity in HCT116 or U-87 MG cancer cultures (up to 10 μM) despite its potent cellular activity (CK2α/CK2α’ IC50 = 36/16 nM by cellular NanoBRET assay). |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |