Synonym: LY 573636; LY-573636; LY573636; N-(2,4-Dichlorobenzoyl)-5-bromothiophene-2-sulfonamide; N-(5-Bromothiophen-2-ylsulfonyl)-2,4-dichlorobenzamide; N-[(5-Bromo-2-thienyl)sulfonyl]-2,4-dichlorobenzamide
CAS Number: 519055-62-0
Empirical Formula (Hill Notation): C11H6BrCl2NO3S2
Molecular Weight: 415.11
MDL Number: MFCD11973637
Linear Formula: C11H6BrCl2NO3S2
Product Type: Chemical
assay |
≥98% (HPLC) |
color |
white to beige |
form |
powder |
Quality Level |
100 ![External link](https://krackeler.com/images/sigma/ext-link.gif) |
solubility |
DMSO: 2 mg/mL, clear |
storage temp. |
2-8°C |
Biochem/physiol Actions: |
Tasisulam (LY573636) is a SPLAM (SPLicing inhibitor sulfonAMide) that bridges RNA binding motif protein 39 (RBM39; CAPERα, HCC1) and DCAF15 for interaction, thereby promoting (CUL4-DDB1-DDA1-DCAF15) E3 ubiquitin ligase complex-mediated RBM39 ubiquitination and subsequent proteasomal degradation. Tasisulam exerts selective toxicity in parental HCT116 cancer cultures (IC50 = 6.5 μM), but not those harboring non-CUL4-DCAF15-associating RBM39 G268V mutant even at a high concentration of 50 μM. |
WGK Germany |
WGK 3 |
Flash Point(F) |
Not applicable |
Flash Point(C) |
Not applicable |
Purity |
≥98% (HPLC) |
Storage Temp. |
2-8°C |
UNSPSC |
12352200 |