MGR1

SIGMA/SML2953 - ≥98% (HPLC)

Synonym: 2,2-Dimethylpropanoic acid [(1,4,4a,9,9a,10-hexahydro-9,10-dioxo-1,4-ethanoanthracen-5-yl)oxy]methyl ester; JCHD precursor

CAS Number: 2361529-46-4
Empirical Formula (Hill Notation): C₂₂H₂₄O₅
Molecular Weight: 368.42
Linear Formula: C₂₂H₂₄O₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML2953-5MG	5 mg	$124.00 1/EA	Add To Favorites
45-SML2953-25MG	25 mg	$495.00 1/EA	Add To Favorites

Properties
Descriptions
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
Quality Level	100
SMILES string	O=C1C2C(C(C3=C1C=CC=C3OCOC(C(C)(C)C)=O)=O)C4C=CC2CC4
solubility	DMSO: 2 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:

MGR1 is an effective reactive oxygen species (ROS) generator in live cells (dosing range 2-100 μM). MGR1 is activated by intracellular esterases to form JCHD (5-hydroxy-1,4,4a,9a-tetrahydro-1,4-ethanoanthracene-9,10-dione), which in turn, facilitated by a proximal H-bonding hydroxyl group, undergoes keto-enol tautomerism for enhanced superoxide (O2•-) generation upon reacting with molecular oxygen (O2). MGR1, but not its inactive analog MGR2, upregulates cellular ROS, resulting in cell death when used at high concentrations (>5 μM; RAW264.7, THP1, HeLa, MCF7, A549).

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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