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Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone Ready Made Solution

SIGMA/SML2959 - ≥98% (HPLC), 2.54 mg/mL (10mM) in DMSO

Synonym: FCCP; Mesoxalonitrile 4-trifluoromethoxyphenylhydrazone

Empirical Formula (Hill Notation): C10H5F3N4O
Molecular Weight: 254.17
Linear Formula: C10H5F3N4O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML2959-1ML 1 mL
 $70.40
1/EA		 Add To Favorites
assay ≥98% (HPLC)
form liquid
Quality Level 100 
storage temp. −20°C
Biochem/physiol Actions: Mithophagy inducer, ionophore
General description: Carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone (FCCP) is a proton (H+) ionophore and a potent mitochondrial uncoupling agent. This compound turns the mitochondrial membrane permeable to protons, thus dissipating the mitochondrial membrane potential and uncouples oxidative phosphorylation from ATP synthesis. FCCP is a potent tool for assaying mitochondrial respiration and investigating the role of mitochondria in cellular function.1,2FCCP induces mitophagy of SH-SY5Y neuroblastoma cell in a dose dependent manner. Low concentration of FCCP (1μM) leads to a complete loss of mitochondrial membrane potential without triggering mitophagy, whereas at a high concentration (10 μM), cytosol acidification is increased and mitochondrial degradation is attained.3 Additionally, FCCP (20 μM) was able to induce apoptosis in lymphoid (CCRF-CEM) and myeloid (HL60) cells after 24hrs of incubation. 4 FCCP (0.5nM-5 μM) reduces β-amyloid peptide production in K695sw cells without altering the β-amyloid precursor protein maturation or synthesis.5 Partial uncoupling of mitochondrial oxidative phosphorylation induced by FCCP (0.3 -3μM) reduces micromotion and wound healing migration of human mesenchymal stem cells.6 Inhibition of F1F0-ATPase by FCCP (10 μM), reduces the impairment of electromechanical activity in human myocardium.7
Other Notes: FCCP ready made solution is a DMSO based solution at 10mM concentration. It is recommended to further dilute in a suitable media to achieve a working concentration of 1-10 μM.
WGK Germany WGK 2
Flash Point(F) 188.6 °F
Flash Point(C) 87 °C
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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