Apilimod
SIGMA/SML2974 - ≥98% (HPLC)
Synonym: 3-
CAS Number: 541550-19-0
Empirical Formula (Hill Notation): C23H26N6O2
Molecular Weight: 418.49
MDL Number: MFCD09954108
Linear Formula: C23H26N6O2
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| Quality Level | 100  |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | −20°C |
| Biochem/physiol Actions: | Apilimod (STA-5326) is a potent, orally active and selective inhibitor of the cytokines IL-12 and IL-23. Apilimod selectively suppresses synthesis of IL-12 and IL-23 by inhibition of phosphotransferase activity of TLR-4 regulator lipid kinase PIKfyve (phosphatidylinositol-3-p<WBR>hosphate 5-kinase). It suppresses Th1 cells response <I>in vivo</I> and reduces inflammatory histopathologic changes. Also, it exhibits strong anti COVID-19 activity in two cell lines (Vero E6:IC<SUB>50</SUB> < 0.08 μM; A549-ACE2:IC<SUB>50</SUB> = 0.007 μM). Apilimod potently reduces entry of SARS-CoV S pseudovirions on 293/hACE2 cells. |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |