Synonym: NA-1, trifluoroacetate salt; Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Leu-Ser-Ser-Ile-Glu-Ser-Asp-Val, trifluoroacetate salt; YGRKKRRQRRR-KLSSIESDV, trifluoroacetate salt
CAS Number: 500992-11-0 (free base)
Empirical Formula (Hill Notation): C105H188N42O30 · xC2HF3O2
Molecular Weight: 2518.88 (free base basis)
Linear Formula: C105H188N42O30 · xC2HF3O2
Product Type: Chemical
assay |
≥95% (HPLC) |
color |
white to off-white |
form |
powder |
Quality Level |
100 ![External link](https://krackeler.com/images/sigma/ext-link.gif) |
storage temp. |
−20°C |
Biochem/physiol Actions: |
Tat-NR2B9c (NA-1) is a 20-mer peptide composed of a membrane-permeant HIV-1 Tat protein transduction domain sequence (a.a. 47-57) N-terminal to the NMDA receptor (NMDAR) GluN2B carboxyl tail sequence KLSSIESDV that blocks intracellular NMDAR-PSD-95 interaction-induced neurotoxic signaling without affecting NMDAR-mediated synaptic activity or calcium influx. NA-1 protects cultured cortical neurons from NMDA excitotoxicity (50 nM; 20/40/100 μM NMDA) and reduces focal ischemic brain damage in rats in vivo (3 μmol/kg iv. bolus 1 hr post MCAO onset). |
WGK Germany |
WGK 3 |
Flash Point(F) |
Not applicable |
Flash Point(C) |
Not applicable |
Purity |
≥95% (HPLC) |
Storage Temp. |
−20°C |
UNSPSC |
12352200 |