OSMI-2
SIGMA/SML2989 - ≥98% (HPLC)
Synonym: (R)-Methyl 2-
CAS Number: 2260542-60-5
Empirical Formula (Hill Notation): C26H25N3O7S2
Molecular Weight: 555.62
Linear Formula: C26H25N3O7S2
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
optical activity | [α]/D -175.0 to -135.0°, c = 1.0 in chloroform-d |
Quality Level | 100 ![]() |
SMILES string | O=C(N1)C=CC2=C1C=CC(S(N[C |
solubility | DMSO: 2 mg/mL, clear |
storage temp. | −20°C |
Biochem/physiol Actions: | OSMI-2 is a cell-permeable precursor of an active site-targeting (Kd = 140 nM) O-GlcNAc transferase (OGT) inhibitor. Upon cell entry, OSMI-2 is activated by cellular esterase to the active inhibitor that effectively downregulates cellular protein O-GlcNAc level (20-40 μM for 4 h/HCT116, 50 μM for 24 h/HEK293T) and renders LNCaP prostate cancer cells dependent on CDK9 for growth (confluency post 96-hr treatment = 73% with 40 μM OSMI-2, 56% with 0.5 μM AT7519, 19% with co-treatment; control cells at 20% and 81% at 0 and 96 hr, respectively). |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |