dCeMM2
SIGMA/SML2990 - ≥98% (HPLC)
Synonym: 2-
CAS Number: 296771-07-8
Empirical Formula (Hill Notation): C16H11ClN6OS
Molecular Weight: 370.82
Linear Formula: C16H11ClN6OS
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
Quality Level | 100 ![]() |
SMILES string | O=C(NC1=NC=C(Cl)C=C1)CSC2 |
solubility | DMSO: 2 mg/mL, clear |
storage temp. | 2-8°C |
Biochem/physiol Actions: | dCeMM2 is a cell penetrant molecular glue degrader that induce ubiquitination and degradation of cyclin K by inciting an interaction of CDK12–cyclin K with a CRL4B ligase complex. dCeMM2 induced proximity between CDK12–cyclin K and the CRL complex adaptor protein DDB1 that causes ubiquitination and proteasomal degradation of cyclin K. |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |