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uPSEM792 hydrochloride

SIGMA/SML2992 - ≥98% (HPLC)

Synonym: 1-Methyl-7,8,9,10-tetrahydro-1H-6,10-methanoazepino[4,5-g]quinoxalin-2(6H)-one hydrochloride; PSEM 792 hydrochloride

CAS Number: 2341841-08-3
Empirical Formula (Hill Notation): C14H15N3O · HCl
Molecular Weight: 277.75
Linear Formula: C14H15N3O · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML2992-5MG 5 mg
 $178.00
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45-SML2992-25MG 25 mg
 $715.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
Quality Level 100 
SMILES string O=C1N(C)C2=CC(C3CNCC4C3)=C4C=C2N=C1.Cl
solubility DMSO: 2 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: uPSEM792 is a selective and ultrapotent pharmacologically selective effector molecule (uPSEM) agonist for chimeric pharmacologically selective actuator modules (PSAMs) with mutant nAChR α7 ligand-binding domain (LBD) PSML181G/Q139L/Y217F (PSAM4) fused to the ion pore domain (IPD) of ligand-gated ion channels (LGICs), including glycine receptor (PSAM4-GlyR EC50 = 2.3 nM) and 5-HT3 (PSAM4-5-HT3 EC50 = 1.6 nM). uPSEM792 exhibits high PSM4 selectivity (>10,000-fold over α7-GlyR, α7-5HT3, 5HT3; >230-fold over α4β2 nAChR) and sub-nanomolar PSAM4-GlyR affinity (Ki = 0.7 nM).
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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