uPSEM792 hydrochloride
SIGMA/SML2992 - ≥98% (HPLC)
Synonym: 1-
CAS Number: 2341841-08-3
Empirical Formula (Hill Notation): C14H15N3O · HCl
Molecular Weight: 277.75
Linear Formula: C14H15N3O · HCl
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
Quality Level | 100 ![]() |
SMILES string | O=C1N(C)C2=CC(C3CNCC4C3)= |
solubility | DMSO: 2 mg/mL, clear |
storage temp. | 2-8°C |
Biochem/physiol Actions: | uPSEM792 is a selective and ultrapotent pharmacologically selective effector molecule (uPSEM) agonist for chimeric pharmacologically selective actuator modules (PSAMs) with mutant nAChR α7 ligand-binding domain (LBD) PSML181G/Q139L/Y217F (PSAM4) fused to the ion pore domain (IPD) of ligand-gated ion channels (LGICs), including glycine receptor (PSAM4-GlyR EC50 = 2.3 nM) and 5-HT3 (PSAM4-5-HT3 EC50 = 1.6 nM). uPSEM792 exhibits high PSM4 selectivity (>10,000-fold over α7-GlyR, α7-5HT3, 5HT3; >230-fold over α4β2 nAChR) and sub-nanomolar PSAM4-GlyR affinity (Ki = 0.7 nM). |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |