JH-RE-06
SIGMA/SML2993 - ≥98% (HPLC)
Synonym: 8-
CAS Number: 1361227-90-8
Empirical Formula (Hill Notation): C20H16Cl3N3O4
Molecular Weight: 468.72
MDL Number: MFCD32197217
Linear Formula: C20H16Cl3N3O4
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
Quality Level | 100 ![]() |
solubility | DMSO: 2 mg/mL, clear |
storage temp. | 2-8°C |
Biochem/physiol Actions: | JH-RE-06 is a potent and selective inhibitor of REV1-REV7 interaction that induces REV1 dimerization blocking the REV1-REV7 interaction and POL ϲ recruitment. JH-RE-06 potently inhibits translesion synthesis (TLS) and augments cisplatin effectiveness in cultured human and mouse cell lines. It improves effectiveness of cisplatin in A375 tumor xenograft mouse model. |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |