Ripasudil Hydrochloride
SIGMA/SML3000 - ≥98% (HPLC)
Synonym: 4-
CAS Number: 223645-67-8 (free base)
Empirical Formula (Hill Notation): C15H18FN3O2S · xHCl
Molecular Weight: 323.39 (free base basis)
Linear Formula: C15H18FN3O2S · xHCl
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
Quality Level | 100 ![]() |
solubility | H2O: 2 mg/mL, clear |
storage temp. | 2-8°C |
Biochem/physiol Actions: | Ripasudil (K-115) is a more potent and selective rho-associated protein kinase (ROCK) inhibitor (IC50 = 51 nM/ROCK1, 19 nM/ROCK2, 2.1 μM/PKACα, 27 μM/PKC, and 0.37 μM/CaMKII?) than Y-27632 and HA-1077 (Fasudil). Ripasudil demonstrates in vivo efficacy in reducing intraocular pressure (IOP) by stimulating aqueous humour drainage through the trabecular meshwork. |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |