Synonym: 2-(3-(Aminomethyl)pyrrolidin-1-yl)-N-(2,4,5-trichlorophenyl)acetamide dihydrochloride; C19 dihydrochloride; Compound 19 dihydrochloride; N-(2,4,5-Trichlorophenyl)-3-aminomethyl-1-pyrrolidineacetamide dihydrochloride
CAS Number: 2241128-93-6
Empirical Formula (Hill Notation): C13H16Cl3N3O·2HCl
Molecular Weight: 409.57
MDL Number: MFCD31666003
Linear Formula: C13H16Cl3N3O·2HCl
Product Type: Chemical
assay |
≥98% (HPLC) |
color |
white to beige |
form |
powder |
Quality Level |
100 ![External link](https://krackeler.com/images/sigma/ext-link.gif) |
SMILES string |
O=C(CN1CC(CC1)CN)NC2=CC(Cl)=C(C=C2Cl)Cl.Cl.Cl |
solubility |
H2O: 2 mg/mL, clear |
storage temp. |
−20°C |
Biochem/physiol Actions: |
Compound 19 (C19) is a small molecule that directly targets TRPM4 TwinF domain and blocks its interaction with GluN2A/GluN2B (NR2A/NR2B) I4 domain. C19 prevents NMDAR/TRPM4 interaction-dependent excitotoxicity (death protection EC50 = 1.1 μM 24 h post 10-min exposure of primary murine hippocampal neurons to 20 μM NMDA) without affecting, and even enhancing, NMDAR-mediated essential functions. |
WGK Germany |
WGK 3 |
Flash Point(F) |
Not applicable |
Flash Point(C) |
Not applicable |
Purity |
≥98% (HPLC) |
Storage Temp. |
−20°C |
UNSPSC |
12352200 |