SCIO-469

SIGMA/SML3008 - ≥98% (HPLC)

Synonym: 2-(6-Chloro-5-((2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpiperazine-1-carbonyl)-1-methyl-1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide; 6-Chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1-piperazinyl]carbonyl]-N,N,1-trimethyl-a-oxo-1H-indole-3-acetamide; SCIO 469; SCIO469; Scios 469; Scios-469; Scios469; Talmapimod

CAS Number: 309913-83-5
Empirical Formula (Hill Notation): C₂₇H₃₀ClFN₄O₃
Molecular Weight: 513.00
MDL Number: MFCD11973651
Linear Formula: C₂₇H₃₀ClFN₄O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML3008-5MG	5 mg	$143.00 1/EA	Add To Favorites
45-SML3008-25MG	25 mg	$572.00 1/EA	Add To Favorites

Properties
Descriptions
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
Quality Level	100
SMILES string	O=C(C(C1=CN(C2=C1C=C(C(Cl)=C2)C(N3[C@@H](CN([C@H](C3)C)CC4=CC=C(C=C4)F)C)=O)C)=O)N(C)C
solubility	DMSO: 2 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:

SCIO-469 (Talmapimod) is an orally active, potent and selective mitogen-activated protein kinase (MAPK) p38alpha (p38α, MAPK14) inhibitor (IC50 = 9 nM; 10-fold over p38β, >2000-fold over 20 other kinases) with no significant affinity toward a panel of 70 enzymes and receptors. SCIO-469 inhibits multiple myeloma (MM) growth in mice in vivo (150 or 450 mg/kg powder diet; 5T2MM and 5T33MM) and augments proteasome inhibitor in a murine plasmacytoma model of MM (0.2 mg bortezomib/kg i.v. twice weekly with 30 mg SCIO-469/kg b.i.d. p.o.; RPMI8226).

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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