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MG149

SIGMA/SML3011 - ≥98% (HPLC)

Synonym: 2-(4-Heptylphenethyl)-6-hydroxybenzoic acid; 2-[2-(4-Heptylphenyl)ethyl]-6-hydroxybenzoic acid; MG 149

CAS Number: 1243583-85-8
Empirical Formula (Hill Notation): C22H28O3
Molecular Weight: 340.46
MDL Number: MFCD22123243
Linear Formula: C22H28O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML3011-5MG 5 mg
 $143.00
1/EA		 Add To Favorites
45-SML3011-25MG 25 mg
 $457.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
Quality Level 100 
SMILES string OC1=C(C(CCC2=CC=C(C=C2)CCCCCCC)=CC=C1)C(O)=O
solubility DMSO: 2 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: MG149 is cell-permeable anacardic acid analog that displays higher selectivity towards MYST type HATs (IC50 = 47 and 74 μM against MOF and Tip60; Ki for KAT8 = 39 μM) over p300 and PCAF (IC50 > 200 and >> 200 uM). Tip60 inhibition is shown to be Ac-CoA competitive and histone substrate non-competitive and KAT8 inhibition is Ac-CoA uncompetitive. MG149 treatment lowers histone acetylation levels and cellular proliferation rate, induces apoptosis and dose-dependently alters pro-inflammatory cytokines/chemokines expression. Enhances JQ1-induced HIV latency reversal, suppresses NOX transcription and ameliorates ROS levels.
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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