Isoliensinine

SIGMA/SML3024 - ≥98% (HPLC)

Synonym: (+)-Isoliensinine; (1R)-1,2,3,4-Tetrahydro-1-[[4-hydroxy-3-[[(1R)-1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-7-isoquinolinyl]oxy]phenyl]methyl]-6-methoxy-2-methyl-7-isoquinolinol

CAS Number: 6817-41-0
Empirical Formula (Hill Notation): C₃₇H₄₂N₂O₆
Molecular Weight: 610.74
MDL Number: MFCD11042260
Linear Formula: C₃₇H₄₂N₂O₆
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML3024-5MG	5 mg	$89.00 1/EA	Add To Favorites
45-SML3024-25MG	25 mg	$287.00 1/EA	Add To Favorites

Properties
Descriptions
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
optical activity	[α]/D 45.0 to 55.0°, c = 0.5 in acetone
Quality Level	100
SMILES string	CN1[C@H](CC(C=C2)=CC=C2OC)C3=C(C=C(C(OC4=C(O)C=CC(C[C@@H]5C(C=C(O)C(OC)=C6)=C6CCN5C)=C4)=C3)OC)CC1
solubility	DMSO: 2 mg/mL, clear
storage temp.	−20°C

Biochem/physiol Actions:

Isoliensinine is a major bisbenzylisoquinoline alkaloid found in the seed-embryos of Nelumbo nucifera that exhibits potent anticancer, anti-diabetic and anti-pulmonary fibrosis effects. It induces apoptosis in triple negative breast cancer cells through induction of ROS and p38 MAPK/JNK activation, while showing only mild effects on normal MCF-10A cells. Isoliensinine shows chemosensitizing properties in several cancer cells. It appears that if augments cisplatin uptake int cancer cells.

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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