Isoliensinine
SIGMA/SML3024 - ≥98% (HPLC)
Synonym: (+)-Isoliensinine; (1R)
CAS Number: 6817-41-0
Empirical Formula (Hill Notation): C37H42N2O6
Molecular Weight: 610.74
MDL Number: MFCD11042260
Linear Formula: C37H42N2O6
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
optical activity | [α]/D 45.0 to 55.0°, c = 0.5 in acetone |
Quality Level | 100 ![]() |
SMILES string | CN1[C@H](CC(C=C2)=CC=C2OC |
solubility | DMSO: 2 mg/mL, clear |
storage temp. | −20°C |
Biochem/physiol Actions: | Isoliensinine is a major bisbenzylisoquinoline alkaloid found in the seed-embryos of Nelumbo nucifera that exhibits potent anticancer, anti-diabetic and anti-pulmonary fibrosis effects. It induces apoptosis in triple negative breast cancer cells through induction of ROS and p38 MAPK/JNK activation, while showing only mild effects on normal MCF-10A cells. Isoliensinine shows chemosensitizing properties in several cancer cells. It appears that if augments cisplatin uptake int cancer cells. |
Purity | ≥98% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |