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Apostatin-1

SIGMA/SML3028 - ≥98% (HPLC)

Synonym: N-Cycloheptyl-?-[(4,5-dihydro-1-methyl-1H-imidazol-2-yl)thio]-benzeneacetamide

CAS Number: 2559703-06-7
Empirical Formula (Hill Notation): C19H27N3OS
Molecular Weight: 345.50
Linear Formula: C19H27N3OS
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML3028-5MG 5 mg
 $100.00
1/EA		 Add To Favorites
45-SML3028-25MG 25 mg
 $323.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
Quality Level 100 
SMILES string O=C(C(C1=CC=CC=C1)SC2=NCCN2C)NC3CCCCCC3
solubility DMSO: 2 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: Apostatin-1 is a cell penetrant apoptosis inhibitor that activates autophagy leading to restoration of cellular homeostasis in cells with accumulated mutant tau, α-synuclein, or huntingtin. Apostatin-1 potently and selectively inhibits TRADD. It binds to the N-terminal TRAF2-binding domain of TRADD (TRADD-N). Apparently Apostatin-1 releases cIAP1/2 or TRAF2 from TRADD thus promoting the K63-linked ubiquitination of beclin 1.
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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