HG-9-91-01
SIGMA/SML3029 - >95% (HPLC)
Synonym: 1-
CAS Number: 1456858-58-4
Empirical Formula (Hill Notation): C32H37N7O3
Molecular Weight: 567.68
MDL Number: MFCD28167714
Linear Formula: C32H37N7O3
Product Type: Chemical
assay | >95% (HPLC) |
color | white to beige |
form | powder |
Quality Level | 100 ![]() |
SMILES string | O=C(NC1=C(C)C=CC=C1C)N(C2 |
solubility | DMSO: 2 mg/mL, clear |
storage temp. | 2-8°C |
Biochem/physiol Actions: | HG-9-91-01 is an ATP site-targeting WH-4-023 (KIN112) structural analog that inhibits salt-inducible kinases (SIKs) with improved potency (IC50 = 0.6/6.6/9.6 nM against SIK1/2/3) and selectivity, exhibiting significant inhibitory activity only against 4 kinases among a panel of 108 (% inhibition at 100 nM ∼85/EPHA2, 88/EPHA4, 91/Src, 88/YES1) and much reduced or little potency toward the others (by <67% inhibition at 100 nM), including AMPK-related kinases BTK, MARK and NUAK. HG-9-91-01 (500 nM) enhances LPS-induced IL-10 production, while suppresses proinflammatory cytokine secretion from murine marrow-derived macrophages & dendritic cells (BMDMs & BMDCs) as well as primary human macrophages in a CRTC3-dependent manner. A useful tool for studying SIKs-mediated cellular signaling events. |
Purity | >95% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |