JB170
SIGMA/SML3038 - ≥98% (HPLC)
Synonym: 4-
CAS Number: 2705844-82-0
Empirical Formula (Hill Notation): C48H44ClFN8O11
Molecular Weight: 963.36
Linear Formula: C48H44ClFN8O11
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
Quality Level | 100 ![]() |
SMILES string | O=C1N(C2CCC(NC2=O)=O)C(C3 |
solubility | DMSO: 2 mg/mL, clear (Warmed) |
storage temp. | 2-8°C |
Biochem/physiol Actions: | JB170 is a highly specific AURORA-A degrader (PROTAC) comprising aurora kinase inhibitor alisertib connected to the CEREBLON-binding molecule thalidomide. JB170 induces rapid and durable degradation of AURORA-A in cancer cells leading to strong S-phase arrest and apoptosis. |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352107 |