CRBN-6-5-5-VHL
SIGMA/SML3041 - ≥98% (HPLC)
Synonym: CRBN-6-5-5-VHL; (2S,4R)
CAS Number: 2362575-45-7
Empirical Formula (Hill Notation): C51H69N7O10S
Molecular Weight: 972.20
MDL Number: MFCD32705129
Linear Formula: C51H69N7O10S
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
Quality Level | 100 ![]() |
SMILES string | O=C1C2=C(C=CC=C2C(N1C3C(N |
solubility | DMSO: 2 mg/mL, clear |
storage temp. | −20°C |
Biochem/physiol Actions: | CRBN-6-5-5-VHL is a cell-permeable and highly potent heterodimerizer comprising E3 ligases recruiting ligands, namely, pomalidomide and VH032-amine that efficiently knocks down Cereblon (CRBN). CRBN-6-5-5-VHL readily forms heteroternary complex and selectively induces CRBN ubiquitination and proteasomal degradation over VHL in a time- and dose-dependent fashion (0.001 to 1 μM). Higher concentrations (10 μM) causes the degradation of neo-substrates IKZF1 and IKZF3 with no effect on pVHL30 or pVHL19 levels. |
Purity | ≥98% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |