CRBN-6-5-5-VHL

SIGMA/SML3041 - ≥98% (HPLC)

Synonym: CRBN-6-5-5-VHL; (2S,4R)-1-((2S)-2-(5-((5-((6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)oxy)pentyl)oxy)pentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide; CRBN degrader; CRBN directed PROTAC; CRBN-VHL hetero-PROTAC

CAS Number: 2362575-45-7
Empirical Formula (Hill Notation): C₅₁H₆₉N₇O₁₀S
Molecular Weight: 972.20
MDL Number: MFCD32705129
Linear Formula: C₅₁H₆₉N₇O₁₀S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML3041-5MG	5 mg	$404.00 1/EA	Add To Favorites
45-SML3041-25MG	25 mg	$1620.00 1/EA	Add To Favorites

Properties
Descriptions
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
Quality Level	100
SMILES string	O=C1C2=C(C=CC=C2C(N1C3C(NC(CC3)=O)=O)=O)NCCCCCCOCCCCCOCCCCC(N[C@H](C(N4[C@H](C(NCC5=CC=C(C=C5)C6=C(C)N=CS6)=O)C[C@@H](O)C4)=O)C(C)(C)C)=O
solubility	DMSO: 2 mg/mL, clear
storage temp.	−20°C

Biochem/physiol Actions:

CRBN-6-5-5-VHL is a cell-permeable and highly potent heterodimerizer comprising E3 ligases recruiting ligands, namely, pomalidomide and VH032-amine that efficiently knocks down Cereblon (CRBN). CRBN-6-5-5-VHL readily forms heteroternary complex and selectively induces CRBN ubiquitination and proteasomal degradation over VHL in a time- and dose-dependent fashion (0.001 to 1 μM). Higher concentrations (10 μM) causes the degradation of neo-substrates IKZF1 and IKZF3 with no effect on pVHL30 or pVHL19 levels.

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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