iP300
SIGMA/SML3042 - ≥97% (HPLC)
Synonym: 2-(3′-Fluoro-5′-(1-(2-(methylamino)-2-oxoethyl)-1H-pyrazol-4-yl)-2,5-dioxo-2′,3′-dihydrospiro[imidazolidine-4,1′-indene]-1-yl)-N-(4-fluorobenzyl)-N-(1,1,1-trifluoropropan-2-yl)acetamide; 3-
CAS Number: 2624336-90-7
Empirical Formula (Hill Notation): C29H27F5N6O4
Molecular Weight: 618.55
Linear Formula: C29H27F5N6O4
Product Type: Chemical
assay | ≥97% (HPLC) |
color | white to beige |
form | powder |
Quality Level | 100 ![]() |
SMILES string | O=C(NC1(C2=O)CC(C3=C1C=CC |
solubility | DMSO: 2 mg/mL, clear |
storage temp. | −20°C |
Biochem/physiol Actions: | iP300, a mixture of 8 diastereomers, is a potent histone acetyltransferase (HAT) p300/CBP inhibitor (p300 IC50 = 33 nM by H3K9Ac HTRF assay). An active diastereomer(s)-enriched pool (iP300w) obtained by partial HPLC separation prevents DUX4-induced cytotoxicity and transcription activity in human myoblast LHCN-M2 cultures (0.1-1 μM) and shows in vivo efficacy against muscle loss (0.3 mg/kg/day i.p.) in a murine model of facioscapulohumeral muscular dystrophy (FSHD). |
Purity | ≥97% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |