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ppTG21 trifluoroacetate salt

SIGMA/SML3052 - ≥95% (HPLC)

Synonym: GLFHALLHLLHSLWHLLLHA-OH TFA salt; Gly-Leu-Phe-His-Ala-Leu-Leu-His-Leu-Leu-His-Ser-Leu-Trp-His-Leu-Leu-Leu-His-Ala TFA salt

Empirical Formula (Hill Notation): C115H173N31O22 · xC2HF3O2
Molecular Weight: 2341.80 (free base basis)
Linear Formula: C115H173N31O22 · xC2HF3O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML3052-1MG 1 mg
 $118.00
1/EA		 Add To Favorites
assay ≥95% (HPLC)
color white to beige
form film or powder
Quality Level 100 
storage temp. −20°C
Biochem/physiol Actions: ppTG21 is an endosomolytic agent (pI 7.7, charge +1.3 @ pH 7.4) that facilitates cell type-specific gene editing by enabling endosome escape of Cas9 ribonucleoprotein (RNP) complex following its uptake via receptor-mediated endocytosis. Following liver-specific asialoglycoprotein receptor (ASGPr)-mediated delivery of ASGPr ligand (ASGPrL)-harboring & SV40 nuclear localization sequence (NLS)-bearing S. pyogenes Cas9 (Cas9-2lig-1NLS) RNP with EMX1-targeting sgRNA, target gene editing occurs only upon coincubation of the RNP in the presence of 30 molar equiv of ppTG21 (ave 4.8% indels in HepG2 cells vs. 0.2% indels without ppTG21).
Purity ≥95% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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