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CHIR124

SIGMA/SML3054 - ≥98% (HPLC)

Synonym: 4-[((3S)-1-Azabicyclo[2.2.2]oct-3-yl)amino]-3-(1H-benzimidazol-2-yl)-6-chloroquinolin-2(1H)-one; 4-[(3S)-1-Azabicyclo[2.2.2]oct-3-ylamino]-3-(1H-benzimidazol-2-yl)-6-chloro-2(1H)-quinolinone; CHIR 124; CHIR 124; CHIR-124; f 4-[((3S)-quinuclidin-3-yl)amino]-3-benzimidazol-2-yl-6-chloro-hydroquinolin-2- one

CAS Number: 405168-58-3
Empirical Formula (Hill Notation): C23H22ClN5O
Molecular Weight: 419.91
MDL Number: MFCD14636453
Linear Formula: C23H22ClN5O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML3054-5MG 5 mg
 $112.00
1/EA		 Add To Favorites
45-SML3054-25MG 25 mg
 $360.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
Quality Level 100 
SMILES string O=C1NC2=CC=C(Cl)C=C2C(N[C@@H]3CN4CCC3CC4)=C1C5=NC6=C(C=CC=C6)N5
solubility DMSO: 2 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: CHIR124 is a potent and selective inhibitor of checkpoint kinase 1 (Chk1)( IC50 = 0.3 nM) that produces G2-M abrogation which induces chemosensitisation. It also inhibits PDGFR and FLT3 (IC50 = 6.6 nM and 5.8 nM respectively). CHIR-124 inhibits Pgp activity in multidrug-resistant cell lines KB-V1 and A2780-Pac-Res.
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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