Panobinostat
SIGMA/SML3060 - ≥98% (HPLC)
Synonym: (2E)
CAS Number: 404950-80-7
Empirical Formula (Hill Notation): C21H23N3O2
Molecular Weight: 349.43
MDL Number: MFCD09833242
Linear Formula: C21H23N3O2
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
Quality Level | 100 ![]() |
SMILES string | CC1=C(CCNCC2=CC=C(/C=C/C( |
solubility | DMSO: 2 mg/mL, clear |
storage temp. | 2-8°C |
Biochem/physiol Actions: | Panobinostat (LBH589) is an orally active, potent, cinnamoyl hydroxamate-type pan-histone deacetylase inhibitor (class I HDAC1/2/3/8 IC50 = 2.5/13.2/2.1/277 nM; IIA HDAC4/5/7/9 IC50 = 203/7.8/531/5.7 nM; IIB HDAC6/10 IC50 = 10.5/2.3 nM, IV HDAC11 IC50 = 2.7 nM) with anti-cancer efficacy in vitro and in vivo. |
Symbol | ![]() ![]() ![]() |
Signal word | Danger |
Hazard statements | H301 + H331 - H315 - H318 - H360 - H373 |
Precautionary statements | P201 - P280 - P301 + P310 - P302 + P352 - P304 + P340 + P311 - P305 + P351 + P338 |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |