MR6-31-2
SIGMA/SML3242 - ≥98% (HPLC)
Synonym: 2-
Empirical Formula (Hill Notation): C14H10ClNOSe
Molecular Weight: 322.65
Linear Formula: C14H10ClNOSe
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
Quality Level | 100 ![]() |
SMILES string | O=C1N(CC2=CC=C(Cl)C=C2)[S |
storage temp. | 2-8°C |
Biochem/physiol Actions: | MR6-31-2, a CNS penetrant ebselen analog, is a potent inhibitor of SARS-CoV-2 Mpro that bind at the Mpro catalytic site. MR6-31-2 donates a selenium atom, forming a covalent bond and blocking the histidine-Cys catalytic dyad. It exhibits good neuroprotective effects and low cytotoxicity in cell-based and mouse models of motor neuron disease. MR6-31-2 covalently binds to A4V superoxide dismutase-1 (SOD1) and promotes its thermal stability. |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352107 |