Synonym: Bis[2-(2-pyridinyl-kN)phenyl-kC](4,7-dimethoxy-1,10-phenanthroline-kN1, kN10)iridium(III) hexafluorophosphate (1:1); Ir(III) complex 1a
Empirical Formula (Hill Notation): C36H28O2IrN4·PF6
Molecular Weight: 885.81
Linear Formula: C36H28O2IrN4·PF6
Product Type: Chemical
assay |
≥98% (HPLC) |
color |
white to beige |
form |
powder |
Quality Level |
100 ![External link](https://krackeler.com/images/sigma/ext-link.gif) |
solubility |
DMSO: 2 mg/mL, clear |
storage temp. |
2-8°C |
Biochem/physiol Actions: |
HIF-1α stabilizer 1a, a cyclometalated iridium(III) complex, is a cell penetrant stabilizer of hypoxia-inducible factor-1α (HIF-1α) that binds to Von Hippel-Lindau (VHL) tumor suppressor and inhibits the VHL–HIF-1α interaction thereby preventing HIF-1α degradation. HIF-1α stabilizer 1a induces HIF-1α accumulation in cells and activates HIF-1α mediated gene expression. It significantly accelerates wound closure in both normal. |
Purity |
≥98% (HPLC) |
Storage Temp. |
2-8°C |
UNSPSC |
12352200 |