SF3B1 Protein Degrader
SIGMA/SML3252 - ≥95% (HPLC)
Synonym: 2-
Empirical Formula (Hill Notation): C29H29ClN6O5S
Molecular Weight: 609.10
Linear Formula: C29H29ClN6O5S
Product Type: Chemical
assay | ≥95% (HPLC) |
color | white to beige |
form | powder |
Quality Level | 100 ![]() |
SMILES string | O=C1N(C(C2=C1C=CC=C2NCCCC |
solubility | DMSO: 2 mg/mL, clear |
storage condition | under inert gas |
storage temp. | 2-8°C |
Biochem/physiol Actions: | SF3B1 Protein degrader (reported as "PROTAC-O4I2" in Gama-Brambila et al.) is a cell permeable degrader of splicing factor 3B1 (SF3B1) containing an SF3B1 activator O4I2 connected to the ligand of the cereblon ubiquitin ligase thalidomide. PROTAC-O4I2 selectively degrades SF3B1 in cells. It induces apoptosis of tumor cells and extends survival in Drosophila intestinal tumor model. |
Legal Information: | PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license |
Purity | ≥95% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |