JS6

SIGMA/SML3261 - ≥98% (HPLC)

Synonym: 2-(2-Fluorobenzamido)-N-[2-(morpholin-4-yl)ethyl]benzamide; 2-Fluoro-N-(2-(2-morpholinoethylcarbamoyl)phenyl)benzamide; 2-[(2-Fluorobenzoyl)amino]-N-[2-(4-morpholinyl)ethyl]benzamide

CAS Number: 950244-33-4
Empirical Formula (Hill Notation): C₂₀H₂₂FN₃O₃
Molecular Weight: 371.41
Linear Formula: C₂₀H₂₂FN₃O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML3261-25MG		No Price
45-SML3261-5MG		No Price

Properties
Descriptions
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
Quality Level	100
SMILES string	O=C(C1=CC=CC=C1NC(C2=C(C=CC=C2)F)=O)NCCN3CCOCC3
solubility	DMSO: 2 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:

JS6 is a Bcl3:NF-kB p50 protein-protein interaction (PPI) inhibitor that effectively suppresses Bcl3-dependent intracellular NF-kB activity (IC50 = 45/159 nM using Bcl3-overexpressing MDA-MB-231/HEK293; IC50 = 710 nM using HEK293 overexpressing Bcl3 and NF-kB p52). JS6 prevents enhanced MDA-MB-231 migration upon Bcl3 overexpression in cultures (IC50 = 310 nM), and effectively suppresses primary tumor growth as well as secondary tumor colonisation in vivo (3.5-10 mg/kg/d i.p. mice with MDA-MB-436 or 4T1.2 murine carcinoma xenograft) without overt systemic toxicity.

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352107

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