DAPTA trifluoroacetate
SIGMA/SML3265 - ≥95% (HPLC)
Synonym: Adaptavir trifluoroacetate; D-Ala-Peptide T-NH2 trifluoroacetate; D-Ala-Peptide T-amide trifluoroacetate; Dala1-Peptide T-NH2 trifluoroacetate; Dala1-Peptide T-amide trifluoroacetate; H-D-Ala-STTTNYT-NH2 trifluoroacetate; H-
Product Type: Chemical
| assay | ≥95% (HPLC) |
| color | white to off-white |
| form | powder |
| Quality Level | 100  |
| storage temp. | −20°C |
| Biochem/physiol Actions: | DAPTA is a potent CCR5 antagonist, an amidated octapeptide corresponding to an HIV envelope glycoprotein gp120 (gp160)-derived sequence (aa 185-192; the SF-2 isolate) that competes against gp120-CD4 complex for interaction with CCR5 (IC50 = 0.42 nM against gp120CM235 binding to CCR5/CD4 cells, IC50 = 1.5/1.8 nM against gp120BaL/sCD4 or gp120CM235/sCD4 binding to CCR5+/CD4- cells). DAPTA blocks CCR5-dependent HIV host cell entry in cultures and in vivo. |
| Purity | ≥95% (HPLC) |
| Storage Temp. | −20°C |