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AMD070 hydrochloride

SIGMA/SML3266 - ≥98% (HPLC)

Synonym: X4P-001 hydrochloride; (S)-N′-((1H-benzo[d]imidazol-2-yl)methyl)-N′-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine hydrochloride; AMD 070 hydrochloride; AMD 11070 hydrochloride; AMD-070 hydrochloride; AMD-11070 hydrochloride; AMD11070 hydrochloride; N′-(1H-Benzimidazol-2-ylmethyl)-N′-(S)-5,6,7,8-tetrahydro-quinolin-8-yl-butane-1,4-diamine hydrochloride

Empirical Formula (Hill Notation): C21H27N5 · xHCl
Molecular Weight: 349.47 (free base basis)
MDL Number: MFCD23160058
Linear Formula: C21H27N5 · xHCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML3266-25MG
No Price  
45-SML3266-5MG
No Price  

 

assay ≥98% (HPLC)
color white to beige
form powder
Quality Level 100 
SMILES string NCCCCN([C@@H]1C2=NC=CC=C2CCC1)CC3=NC4=C(C=CC=C4)N3.Cl
solubility DMSO: 2 mg/mL, clear
storage condition desiccated
storage temp. 2-8°C
Biochem/physiol Actions: AMD070 (AMD11070) is an orally active, reversible and selective CXCR4 (CD184, fusin) antagonist (IC50 = 13 nM against 100 pM 125I-SDF-1α for binding human CD+/CXCR4+ CEM-CCRF cells) that inhibits HIV-1 replication in cultures (IC50/host cells = 2 nM/MT-4 and 26 nM/PBMCs; T-tropic HIV-1NL4.3 strain) with no host cytotoxicity even at concentrations above 23 μM.
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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