AMD070 hydrochloride
SIGMA/SML3266 - ≥98% (HPLC)
Synonym: X4P-001 hydrochloride; (S)-N′-((1H-benzo[d]imidazol-2-yl)methyl)-N′-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine hydrochloride; AMD 070 hydrochloride; AMD 11070 hydrochloride; AMD-070 hydrochloride; AMD-11070 hydrochloride; AMD11070 hydrochloride; N′-(1H-Benzimidazol-2-ylmethyl)-N′-(S)-5,6,7,8-tetrahydro-quinolin-8-yl-butane-1,4-diamine hydrochloride
Empirical Formula (Hill Notation): C21H27N5 · xHCl
Molecular Weight: 349.47 (free base basis)
MDL Number: MFCD23160058
Linear Formula: C21H27N5 · xHCl
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
Quality Level | 100 ![]() |
SMILES string | NCCCCN([C@@H]1C2=NC=CC=C2 |
solubility | DMSO: 2 mg/mL, clear |
storage condition | desiccated |
storage temp. | 2-8°C |
Biochem/physiol Actions: | AMD070 (AMD11070) is an orally active, reversible and selective CXCR4 (CD184, fusin) antagonist (IC50 = 13 nM against 100 pM 125I-SDF-1α for binding human CD+/CXCR4+ CEM-CCRF cells) that inhibits HIV-1 replication in cultures (IC50/host cells = 2 nM/MT-4 and 26 nM/PBMCs; T-tropic HIV-1NL4.3 strain) with no host cytotoxicity even at concentrations above 23 μM. |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |