AZD5904

SIGMA/SML3274 - ≥95% (HPLC)

Synonym: (R)-3-(2-Tetrahydrofuryl-methyl)-2-thioxanthine; (R)-TX3; 3-[[(2R)-Tetrahydrofuran-2-yl]methyl]-2-thioxo-7H-purin-6-one; AZD 5904; AZD-5904; TX3 R-enantiomer; TX4

CAS Number: 618913-30-7
Empirical Formula (Hill Notation): C₁₀H₁₂N₄O₂S
Molecular Weight: 252.29
Linear Formula: C₁₀H₁₂N₄O₂S
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML3274-25MG		No Price
45-SML3274-5MG		No Price

Properties
Descriptions
Basic Data

assay	≥95% (HPLC)
color	white to beige
form	powder
Quality Level	100
SMILES string	O=C1NC(N(C[C@@H]2OCCC2)C3=C1NC=N3)=S
solubility	DMSO: 2 mg/mL, clear
storage temp.	−20°C

Biochem/physiol Actions:

AZD5904 (TX4) is an orally active 2-thioxanthine class suicide substrate that targets myeloperoxidase (MPO) for mechanism-based inactivation, covalently modifying MPO heme group without converting the enzyme to compound II. AZD5904 effectively inhibits peroxide-induced human MPO chlorination activity (IC50 = 0.2 μM) and extracellular MPO activity in PMA-stimulated human neutrophil cultures (by 68% at 1 μM). Oral administration (20-180 μmol/kg) of the racemate (TX3) is efficacious in reducing inflammation site MPO activity in mice in vivo with 10- to 19-fold selectivity over lactoperoxidase (LPO), thyroid peroxidase (TPO), and >70-fold selectivity over a panel of other enzymes, ion channels, and receptors.

Purity	≥95% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

To Order From a Quote