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AC-262536

SIGMA/SML3278 - ≥95% (HPLC)

Synonym: 4-[(3-endo)-3-Hydroxy-8-azabicyclo[3.2.1]oct-8-yl]-1-naphthalenecarbonitrile; 154BG31; 4-(3-endo-Hydroxy-8-azabicyclo[3.2.1]oct-8-yl)naphthalene-1-carbonitrile; AC 262536; AC262536

CAS Number: 870888-46-3
Empirical Formula (Hill Notation): C18H18N2O
Molecular Weight: 278.35
MDL Number: MFCD24386408
Linear Formula: C18H18N2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML3278-10MG
No Price  
45-SML3278-50MG
No Price  

 

assay ≥95% (HPLC)
color white to beige
form powder
Quality Level 100 
solubility DMSO: 2 mg/mL, clear
storage temp. −20°C
Biochem/physiol Actions: AC-262536 is a non-steroidal, tissue-selective androgen receptor (AR) modulator (SARM) that targets AR with high-affinity (pKi = 8.3 vs. 8.9/testosterone), potency (NIH-3T3/MDA-kb2 reporter assay pEC50 = 7.9/8.8 vs. 8.7/8.5/testosterone) and partial agonist activity (Emax = 67% and 72% of testosterone Emax, respectively by NIH-3T3 or MDA-kb2 assay) and high selectivity (no significant affinity for 47 other human nuclear receptors). AC-262536 antagonizes 10 nM DHT-induced LNCaP proliferation (by 47.2% at 100 nM) and prevents castration-induced LH upregulation in rats in vivo (EC50 = 2.8 mg/kg) with greatly reduced adverse effects than testosterone propionate (TP).
Purity ≥95% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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