AC-262536
SIGMA/SML3278 - ≥95% (HPLC)
Synonym: 4-
CAS Number: 870888-46-3
Empirical Formula (Hill Notation): C18H18N2O
Molecular Weight: 278.35
MDL Number: MFCD24386408
Linear Formula: C18H18N2O
Product Type: Chemical
assay | ≥95% (HPLC) |
color | white to beige |
form | powder |
Quality Level | 100 ![]() |
solubility | DMSO: 2 mg/mL, clear |
storage temp. | −20°C |
Biochem/physiol Actions: | AC-262536 is a non-steroidal, tissue-selective androgen receptor (AR) modulator (SARM) that targets AR with high-affinity (pKi = 8.3 vs. 8.9/testosterone), potency (NIH-3T3/MDA-kb2 reporter assay pEC50 = 7.9/8.8 vs. 8.7/8.5/testosterone) and partial agonist activity (Emax = 67% and 72% of testosterone Emax, respectively by NIH-3T3 or MDA-kb2 assay) and high selectivity (no significant affinity for 47 other human nuclear receptors). AC-262536 antagonizes 10 nM DHT-induced LNCaP proliferation (by 47.2% at 100 nM) and prevents castration-induced LH upregulation in rats in vivo (EC50 = 2.8 mg/kg) with greatly reduced adverse effects than testosterone propionate (TP). |
Purity | ≥95% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |