T-0080
SIGMA/SML3283 - ≥98% (HPLC)
Synonym: T0080; 3-
Empirical Formula (Hill Notation): C24H22F3N3O3
Molecular Weight: 457.44
Linear Formula: C24H22F3N3O3
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
Quality Level | 100 ![]() |
SMILES string | O=C1N(C2CCOCC2)C(C3=CC=C( |
solubility | DMSO: 2 mg/mL, clear |
storage temp. | 2-8°C |
Biochem/physiol Actions: | T-0080 is a blood-brain barrier (BBB)-permeable formyl peptide receptor 1 (FPR1) antagonist that effectively inhibits fMLF-dependent response in human and murine neutrophils cultures (10 nM fMLF-induced human neutrophil Ca2+ response IC50 = 0.85 μM) and attenuates brain edema and improved neurological outcomes in murine intracerebral hemorrhage (ICH) models in vivo (5 mg/kg via daily i.p.) with no short-term adverse effects (up to 2 g/kg p.o.). |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |