Synonym: 4-Methoxy-N-[(1S )-3-methyl-1-[[[(1S )-2-oxo-1-[[(3S )-2-oxo-3-pyrrolidinyl]methyl]-3-(phosphonooxy)propyl]amino]carbonyl]butyl]-1H-indole-2-carboxamide; PF-007304814; (S)-3-((S)-2-(4-Methoxy-1H-indole-2-carboxamido)-4-methylpentanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butyl dihydrogen phosphate; PF 007304814; PF 00835231 phosphate prodrug; PF 07304814; PF 835231 phosphate prodrug; PF-835231 phosphate prodrug; PF007304814; PF07304814; PF835231 phosphate prodrug
CAS Number: 2468015-78-1
Empirical Formula (Hill Notation): C24H33N4O9P
Molecular Weight: 552.51
MDL Number: MFCD33029313
Linear Formula: C24H33N4O9P
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to beige |
| form |
powder |
| Quality Level |
100  |
| solubility |
DMSO: 2 mg/mL, clear |
| storage temp. |
2-8°C |
| Biochem/physiol Actions: |
PF-07304814 is a non-cytotoxic, aqueous soluble phosphate ester prodrug of the potent and selective corona virus inhibitor PF-00835231 (pro-/active drug SARS CoV-2 Ki = 174/0.27 nM). PF-07304814 is rapidly converted to PF-00835231, exhibiting anti-viral efficacy in cultures (PF-07304814/PF-00835231 IC50 with 2 μM P-pg efflux inhibitor CP-100356 = 3.8/0.24 μM (SARS2 Washington 1 & Vero E6-enACE2), 830/760 nM (SARS2 BetaCov GHB-03021/2020 & Vero E6-EGFP); PF-07304814/PF-00835231 IC50 with 0.5 μM CP-100356 = 58/80 nM (HCoV-229E & MRC-5)) without affecting P450 enzymes (>100 μM) or a range of transporters (>130 μM). |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
