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STM2457

SIGMA/SML3360 - ≥98% (HPLC)

Synonym: N-[(6-{[(Cyclohexylmethyl)amino]methyl}imidazo[1,2-a]pyridin-2-yl)methyl]-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxamide; STM 2457; STM-2457

CAS Number: 2499663-01-1
Empirical Formula (Hill Notation): C25H28N6O2
Molecular Weight: 444.53
Linear Formula: C25H28N6O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML3360-25MG
No Price  
45-SML3360-5MG
No Price  

 

assay ≥98% (HPLC)
color white to beige
form powder
Quality Level 100 
SMILES string O=C1C=C(C(NCC2=CN3C=C(CNCC4CCCCC4)C=CC3=N2)=O)N=C5C=CC=CN15
solubility DMSO: 2 mg/mL, clear
storage temp. −20°C
Biochem/physiol Actions: STM2457 is a potent and highly selective SAM-binding site METTL3 (MT-A70) m6A methyltransferase inhibitor (IC50 = 16.9 nM, Kd = 1.4 nM by SPR, using METTL3-METTL14 complex; no potency toward other RNA/DNA/protein methyltransferases or 486 kinases). STM2457 selectively inhibits human AML proliferation (IC50 = 0.6-10.3 µM) and the clonogenic potential of primary mouse AML, but not normal mouse haematopoietic stem/progenitor or human cord blood CD34+ cells. STM2457 impairs the expansion of AML patient-derived xenografts in mice in vivo (50 mg/kg i.p.) and significantly prolongs the animal′s lifespan. STM2457 is also reported to restrict β-coronavirus replication and spread.
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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