Sirtuin 6 human

SIGMA/SRP0120 - recombinant, expressed in E. coli, ≥70% (SDS-PAGE)

Synonym: NAD-dependent ADP-ribosyltransferase sirtuin-6; SIR2L6; SIRT6; sir2-like 6

Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SRP0120-100UG	100 µg	$653.00 1/EA		Add To Favorites

SDS-PAGE Sirtuin 6: Cat. No. SRP0120: Coomassie blue-stained SDS-PAGE analysis of Sirtuin 6

Properties
Descriptions
Basic Data

assay	≥70% (SDS-PAGE)
biological source	human
concentration	>0.02 mg/mL
form	aqueous solution
mol wt	65 kDa
NCBI accession no.	NM_016539
packaging	pkg of 100 μg
recombinant	expressed in E. coli
shipped in	dry ice
storage condition	avoid repeated freeze/thaw cycles
storage temp.	−70°C
UniProt accession no.	Q8N6T7

Application:	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Biochem/physiol Actions:	Sirtuin 6 (Sir6) is a mono-ADP-ribosyltransferase, which catalyzes the transfer of ADP-ribose moiety from NAD to itself and histones. It has been implicated in the regulation of DNA repair, genomic stability and telomere integrity, gene expression, and metabolism. In addition, it also prevents age-related disorders and premature aging. Sir6 plays a vital role in the inhibition of nuclear factor-κB (NF-κB)–mediated inflammatory responses in rheumatoid joints. Hence, Sir6 is considered to be a potent target for treatment of rheumatoid arthritis (RA). Sir6 is also majorly implicated in the regulation of glucose and fat metabolism. Sir6 prevent cardiac hypertrophy in vitro via inhibiting NF-κB-dependent transcriptional activity and this effect is relied on its deacetylase activity.
General description:	Sirtuin 6 (Sir6) is encoded by the gene mapped to human chromosome 19p13.3, a region linked with development of acute leukemia. Sir 6 is mainly expressed in bone cells and in the ovaries, but it is absent in the bone marrow. Sirt6 is a chromatin-associated protein localized specifically in nucleus. Human Sirtuin 6, GenBank Accession No. NM_016539), full length with N-terminal ST tag, MW = 65kDa, expressed in Escherichia coli expression system.
Physical form:	Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20 and 20% glycerol.
Preparation Note:	Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.

Purity	≥70% (SDS-PAGE)
Storage Temp.	−70°C
UNSPSC	12352200

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