Sirtuin 6 human
SIGMA/SRP0120 - recombinant, expressed in E. coli, ≥70% (SDS-PAGE)
Synonym: NAD-dependent ADP-
Product Type: Chemical
assay | ≥70% (SDS-PAGE) |
biological source | human |
concentration | >0.02 mg/mL |
form | aqueous solution |
mol wt | 65 kDa |
NCBI accession no. | NM_016539 ![]() ![]() |
packaging | pkg of 100 μg |
recombinant | expressed in E. coli |
shipped in | dry ice |
storage condition | avoid repeated freeze/thaw cycles |
storage temp. | −70°C |
UniProt accession no. | Q8N6T7 ![]() ![]() |
Application: | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Biochem/physiol Actions: | Sirtuin 6 (Sir6) is a mono-ADP-ribosyltransfera |
General description: | Sirtuin 6 (Sir6) is encoded by the gene mapped to human chromosome 19p13.3, a region linked with development of acute leukemia. Sir 6 is mainly expressed in bone cells and in the ovaries, but it is absent in the bone marrow. Sirt6 is a chromatin-associated protein localized specifically in nucleus. Human Sirtuin 6, GenBank Accession No. NM_016539), full length with N-terminal ST tag, MW = 65kDa, expressed in Escherichia coli expression system. |
Physical form: | Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20 and 20% glycerol. |
Preparation Note: | Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles. |
Purity | ≥70% (SDS-PAGE) |
Storage Temp. | −70°C |
UNSPSC | 12352200 |