DNMT2 Active human

SIGMA/SRP0127 - recombinant, expressed in baculovirus infected insect cells, ≥80% (SDS-PAGE)

Synonym: DNA (cytosine-5-)-methyltransferase 2; PUMET; RNMT1; tRNA (cytosine-5-)-methyltransferas; tRNA aspartic acid methyltransferase 1

Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SRP0127-10UG	10 µg	$687.00 1/EA		Add To Favorites

SDS-PAGE DNMT2: Cat. No. SRP0127: Coomassie blue-stained SDS-PAGE analysis of DNMT2

Properties
Descriptions
Basic Data

assay	≥80% (SDS-PAGE)
biological source	human
concentration	>0.02 mg/mL
form	aqueous solution
mol wt	71 kDa
NCBI accession no.	NM_004412
packaging	pkg of 10 μg
recombinant	expressed in baculovirus infected insect cells
shipped in	dry ice
storage temp.	−70°C
UniProt accession no.	Q6ICS7

Application:	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Biochem/physiol Actions:	DNA (cytosine-5-)-methyltransferase 2 (DNMT2) methylates the cytosine-38 residue of the aspartic acid transfer RNA (tRNA-Asp). It has been shown to interact with the anticodon stem and loop. The protein also functions in cellular physiology and stress response. It is significantly expressed in cancers.
General description:	DNA (cytosine-5-)-methyltransferase 2 (DNMT2) is a highly conserved protein which is part of the DNA methyltransferase family. It possesses a conserved cysteine residue in its catalytic pocket. The gene encoding it is localized on human chromosome 10p14->p12.
Physical form:	Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20 and 10% glycerol.
Preparation Note:	Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.

Purity	≥80% (SDS-PAGE)
Storage Temp.	−70°C
UNSPSC	12352200

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