PRL-1 (2-173) Active human

SIGMA/SRP0208 - recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Synonym: PRL-1; PTP4A1; Protein tyrosine phosphatase type IVA, member 1; Protein-tyrosine phosphatase of regenerating liver 1

Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SRP0208-50UG	50 µg	$568.00 1/EA	Add To Favorites

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Properties
Descriptions
Basic Data

assay	≥90% (SDS-PAGE)
biological source	human
concentration	>0.02 mg/mL
form	aqueous solution
mol wt	19.8 kDa
NCBI accession no.	BC023975
packaging	pkg of 50 μg
recombinant	expressed in E. coli
shipped in	dry ice
storage condition	avoid repeated freeze/thaw cycles
storage temp.	−70°C
UniProt accession no.	Q93096

Application:	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Biochem/physiol Actions:	Protein-tyrosine-phosphatase of regenerating liver 1 (PRL1) or protein tyrosine phosphatase type IVA, member 1 (PTP4A1) regulates cancer-related signaling pathways, which are downstream of epidermal growth factor receptor (EGFR) pathway and stimulates cell proliferation, invasion and migration. PRL1 acts as a potential therapeutic target and predictor for patient survival in prostate cancer (PCa) including those with castration-resistant prostate cancer (CRPC). PRL1 is essential for normal mitotic process. Elevated expressions of prenylated protein tyrosine phosphatases (PTPs) in mammalian cells conferred a transformed phenotype, which might be involved in the tumorigenesis.
General description:	Human PRL 1 (GenBank Accession No. BC023975), (amino acids 2-173) with N-terminal HIS tag, MW = 19.8 kDa, expressed in an E. coli expression system.
General description:	Protein-tyrosine-phosphatase of regenerating liver 1 (PRL1), also known as protein tyrosine phosphatase type IVA, member 1 (PTP4A1), is encoded by the gene mapped to human chromosome 6q12. The encoded protein is a member of a small class of prenylated protein tyrosine phosphatases (PTPs). It is characterized by a PTP domain and a specific C-terminal prenylation motif. PRL1 is mainly localized to the cell membrane and the endoplasmic reticulum depending on its C-terminal prenylation.
Other Notes:	One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 30°C.
Physical form:	Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 20% glycerol and 3 mM DTT.
Preparation Note:	Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.

Purity	≥90% (SDS-PAGE)
Storage Temp.	−70°C
UNSPSC	51111800

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