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Cofilin 1 Active human

SIGMA/SRP0254 - recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Synonym: CFL1; Cofilin, non-muscle isoform; p18

Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-SRP0254-200UG 200 µg
$648.00
1/EA
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SDS-PAGE Cofilin 1 : Cat. No. SRP0254: Coomassie blue-stained SDS-PAGE analysis of Cofilin 1

 

assay ≥90% (SDS-PAGE)
biological source human
concentration >0.02 mg/mL
form aqueous solution
mol wt 44 kDa
NCBI accession no. NM_005507 
packaging pkg of 200 μg
recombinant expressed in E. coli
shipped in dry ice
storage temp. −70°C
UniProt accession no. P23528 
Application: Kinase substrate for the kinase assay; western blot
Biochem/physiol Actions: Cofilin-l (CFL1) plays a vital role in the regulation of actin cytoskeleton reorganization. It is also implicated in cancer cell migration and invasion in several types of tumor tissues. Elevated expression of the gene is associated with the development of esophageal squamous cell carcinoma (ESCC). In addition, abnormal expression of the gene leads to vulvar cancer and thus, it can be considered as a potential therapeutic target for the same. CFL1 facilitates cytokinesis, cell motility and morphogenesis. Activated CFL1 helps in preventing cytoskeletal-associated defects in axonal development stimulated by Syns.
General description: Cofilin 1 is ubiquitously expressed and has a molecular mass of ~19kDa.
General description: Human recombinant Cofilin1 (2-end) with N-terminal GST tag (GenBank Accession No. NM_005507), expressed in a E. coli expression system. Cofilin 1, MW = 44 kDa,
Physical form: Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 30% glycerol and 3 mM DTT.
Preparation Note: Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.
RIDADR NONH for all modes of transport
WGK Germany WGK 1
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥90% (SDS-PAGE)
Storage Temp. −70°C
UNSPSC 12352202

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