HDAC/SIRT Substrate 1, fluorogenic
SIGMA/SRP0305 - ≥90% (HPLC)
Synonym: HDAC; histone deacetylase
Product Type: Chemical
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| assay | ≥90% (HPLC) |
| form | aqueous solution |
| packaging | pkg of 500 nmol |
| shipped in | dry ice |
| storage temp. | −70°C |
| Application: | Study enzyme kinetics, and screen small molecule inhibitors for drug discovery and HTS applications. |
| General description: | A fluorogenic, acetylated peptide substrate for HDAC′s. Based on residues 379-382 of p53, Arg-His-Lys-Lys, Ac, a site of regulatory acetylation by the p300 and CBP acetyltransferases, lysines 381, 382, 1-3, it is a suitable substrate for HDAC2, HDAC3, and HDAC6 tested so far. |
| Physical form: | Supplied as a 5 mM solution in DMSO. |
| WGK Germany | WGK 3 |
| Flash Point(F) | 188.6 °F - closed cup |
| Flash Point(C) | 87 °C - closed cup |
| Purity | ≥90% (HPLC) |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |