ATAT1 human
SIGMA/SRP0309 - recombinant, expressed in E. coli, ≥55% (SDS-PAGE)
Synonym: MEC17; TAT; alpha tubulin acetyltransferase 1
Product Type: Chemical
SDS-PAGE ATAT1 Human: Cat. No. SRP0309: Coomassie blue-stained SDS-PAGE analysis of ATAT1. Lanes 1. 3.2 μg ATAT1. 2. Protein Marker.
| assay | ≥55% (SDS-PAGE) |
| biological source | human |
| form | aqueous solution |
| mol wt | 52 kDa |
| NCBI accession no. | NM_001031722 (var1)   |
| packaging | pkg of 50 μg |
| recombinant | expressed in E. coli |
| shipped in | dry ice |
| storage temp. | −70°C |
| UniProt accession no. | Q5SQI0 |
| Biochem/physiol Actions: | ATAT1 (α tubulin acetyltransferase 1) catalyses the acetylation of lysine 40 of α-tubulin and microtubule. ATAT1 expression is essential for microtubule stabilization and mediates cilium formation. Upart from acetylation, αTAT1 interacts with doublecortin (a microtubule associated protein) to degrade microtubules that are not aligned with acetyltransferase activity. αTAT1 regulates the Wnt1 signalling pathway via β-catenin and promotes tumorigenesis. Overexpression of the ATAT1 gene is observed in colon cancer and is known to contribute to its progression. |
| General description: | Human α tubulin acetyltransferase 1, or ATAT1, (GenBank Accession No. NM_001031722 (var1)), amino acids 2 – 224 with N-terminal GST-tag, MW=52 kDa, expressed in an E. coli expression system. The αTAT1 (α tubulin acetyltransferase 1) protein sequence of αTAT1 is highly conserved among eukaryotes. αTAT1 is a member of Gcn5 (general control non-depressible 5)-related N-acetyltransferase superfamily and is mostly present in ciliated organisms. It has also been identified in Tetrahymena, nematodes, zebrafish and mice. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥55% (SDS-PAGE) |
| Storage Temp. | −70°C |
| UNSPSC | 12352202 |