HDAC6 H216A human
SIGMA/SRP0310 - recombinant, expressed in baculovirus infected Sf9 cells, ≥75% (SDS-PAGE)
Synonym: HD6; JM21; histone deacetylase 6
Product Type: Chemical
SDS-PAGE HDAC6 H216A Human : Cat. No. SRP0310: Coomassie blue-stained SDS-PAGE analysis of HDAC6 H216A. Lanes 1. 3 μg HDAC6 H216A. 2. Protein Marker.
Chart HDAC6 H216A Human : Cat. No. SRP0310: Activity assay of HDAC6 H216A Human.
| assay | ≥75% (SDS-PAGE) |
| biological source | human |
| concentration | 0.65 mg/mL |
| form | aqueous solution |
| mol wt | 161 kDa |
| NCBI accession no. | NM_006044   |
| packaging | pkg of 50 μg |
| recombinant | expressed in baculovirus infected Sf9 cells |
| shipped in | dry ice |
| storage condition | avoid repeated freeze/thaw cycles |
| storage temp. | −70°C |
| UniProt accession no. | Q9UBN7 |
| Biochem/physiol Actions: | HDAC6 (histone deacetylase 6) is involved in the control of microtubules, growth factor-mediated chemotaxis, stress response in presence of misfolded protein and tumor invasion. It also participates in EGF (epidermal growth factor)-mediated β-catenin nuclear presence and activation of c-myc. In mouse model, HDAC6 is implicated in oncogene-induced tumorigenesis. HDAC6 is the main deacetylase for α-tubulin and thus, is involved in cell motility. It is also involved in the formation of SGs (stress granules) and SG proteins. Mutations in the 3′-UTR of the HDAC6 gene suppresses hsa-miR-433-mediated post-transcriptional regulation. This results in overexpression of HDAC6, thereby causing X-linked chondrodysplasia. |
| General description: | HDAC6 (histone deacetylase 6) belongs to the HDAC family of proteins. HDACs are responsible for deacetylation of nuclear histone and nonhistone proteins, including transcription factors. The mutation H216A results in catalytically inactive HDAC6. Human HDAC6 with H216A mutation (GenBank Accession No. NM_006044), full length with N-terminal GST tag, MW= 161kDa, expressed in a Baculovirus expression system. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥75% (SDS-PAGE) |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |