JMJD2A active human
SIGMA/SRP0319 - recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
Synonym: JHDM3A; KDM4A; lysine (K)-specific demethylase 4A
Product Type: Chemical
SDS-PAGE JMJD2A active Human : Cat. No. SRP0319: Coommassie blue-stained SDS-PAGE analysis of JMJD2A(KDM4A). Lanes 1. 12 μg JMJD2A(KDM4A). 2. Protein Marker.
Chart JMJD2A active Human : Cat. No. SRP0319: Activity assay of JMJD2A(KDM4A) Active Human.
| assay | ≥80% (SDS-PAGE) |
| biological source | human |
| concentration | 1 mg/mL |
| form | aqueous solution |
| mol wt | 42 kDa |
| NCBI accession no. | NM_014663   |
| packaging | pkg of 100 μg |
| recombinant | expressed in E. coli |
| shipped in | dry ice |
| storage condition | avoid repeated freeze/thaw cycles |
| storage temp. | −70°C |
| UniProt accession no. | O75164 |
| Biochem/physiol Actions: | JMJD2A (Jumonji domain containing 2A) acts as a repressor of transcription, and interacts with histone deacetylase complexes and Rb (retinoblastoma) protein. In histone H3, H3K9me2/3 and H3K36me2/3, this protein is responsible for the demethylation of di- and trimethylated Lys9 and Lys36 residues. It is up-regulated in breast cancer and is responsible for the transcriptional repression of the tumor suppressor ARHI (aplasia Ras homolog member I) which eventually promotes breast cancer proliferation, migration and invasion. |
| General description: | Human JMJD2A, also known as JHDM3A and KDM4A (GenBank Accession No. NM_014663), amino-acids 1-350 with N-terminal His-tag, MW=42 kDa, expressed in an E.coli expression system. |
| General description: | JMJD2A (Jumonji domain containing 2A) belongs to the conserved family of Jmjc domain-containing proteins, which in turn are a part of the Jmjc domain histone demethylase superfamily. JMJD2A protein is composed of 1064 amino acids, and contains JmjN and JmjC domains in the catalytic core, a linker region of 350 residues, two plant homeodomains (PHD), and a double Tudor domain. It is one of the six JMJD2 homologs found in humans, ranging from JMJD2A to JMJD2F. It is a trimethyllysine-specific JmjC histone demethylase (HDM). |
| Symbol |   GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H315 - H319 - H360D |
| Precautionary statements | P201 - P305 + P351 + P338 - P308 + P313 |
| Hazard Codes | T |
| Risk Statements | 61 |
| Safety Statements | 53-45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥80% (SDS-PAGE) |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |