PDGFRb active human
SIGMA/SRP0351 - recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE)
Synonym: CD140B; JTK12; platelet-derived growth factor receptor, beta polypeptide
CAS Number: 101463-26-7
Product Type: Chemical
SDS-PAGE PDGFRb active Human : Cat. No. SRP0351: Coommassie blue-stained SDS-PAGE analysis of PDGFRb. Lanes 1. 5 μg PDGFRb. 2. Protein Marker.
Chart PDGFRb active Human : Cat. No. SRP0351: Activity assay of PDGFRb Active Human.
| assay | ≥70% (SDS-PAGE) |
| biological source | human |
| form | aqueous solution |
| mol wt | 62 kDa |
| NCBI accession no. | NM_002609   |
| packaging | pkg of 10 μg |
| recombinant | expressed in baculovirus infected Sf9 cells |
| shipped in | dry ice |
| solubility | soluble |
| water: soluble | |
| storage temp. | −70°C |
| technique(s) | activity assay: suitable |
| inhibition assay: suitable | |
| UniProt accession no. | P09619 |
| Application: | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
| Biochem/physiol Actions: | The PDGFβ receptor is involved in the development of the kidney, heart, placenta, blood vessels, and cardiovascular system. It also helps to regulate interstitial fluid pressure in tissues thus preventing edema. The activation of the PDGFβ receptor plays a crucial role in the process of wound healing. In addition to these functions, its overexpression is related to gastric cancer. |
| General description: | Research area: Cell Cycle Human PDGFRbeta (GenBank Accession No. NM_002609), cytoplasmic domain, amino acids 558-1106 (end) with N-terminal His-tag, MW= 62 kDa, expressed in Sf9 cells via a Baculovirus expression system. Platelet-derived growth factor receptor (PDGFR) belongs to subclass III of receptor tyrosine kinases. The PDGFR exists as two isoforms, PDGFa and PDGFb-receptors, consisting of five extracellular immunoglobulin (Ig) loops and an intracellular tyrosine kinase (TK) domain. |
| Symbol |   GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H315 - H319 - H360D |
| Precautionary statements | P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313 |
| Hazard Codes | T |
| Risk Statements | 61 |
| Safety Statements | 53-45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥70% (SDS-PAGE) |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |