LOXL2 human
SIGMA/SRP0375 - recombinant, expressed in FreeStyle™ 293-F cells, ≥86% (SDS-PAGE)
Synonym: LOR2; WS9-14; lysyl oxidase-like 2
Product Type: Chemical
SDS-PAGE LOXL2 Human : Cat. No. SRP0375: Coommassie blue-stained SDS-PAGE analysis of LOXL2. Lanes 1. 2 μg LOXL2. 2. Protein Marker.
| assay | ≥86% (SDS-PAGE) |
| biological source | human |
| concentration | 0.23 mg/mL |
| form | aqueous solution |
| mol wt | 85 kDa |
| NCBI accession no. | NM_002318   |
| packaging | pkg of 10 μg |
| recombinant | expressed in FreeStyle™ 293-F cells |
| shipped in | dry ice |
| storage condition | avoid repeated freeze/thaw cycles |
| storage temp. | −70°C |
| UniProt accession no. | Q9Y4K0 |
| Biochem/physiol Actions: | Lysyl oxidase like 2 (LOXL2) is an amino oxidase. LOXL2 is involved in various cellular events such as gene transcription, cell migration, adhesion and differentiation. The protein has a role in connecting collagen and/or elastin in the extracellular matrix. It deaminates trimethylated lysine 4 in histone H3, causing transcriptional repression. LOXL2 suppresses some TFIID (transcription factor IID)-associated genes by oxidising methylated TAF10 (TATA-box binding protein associated factor 10). The LOXL2 gene is upregulated in various cancers, such as gastric cancer, breast cancer and squamous cell carcinomas. The gene is associated with cancer cell invasion and lymph node metastasis. |
| General description: | Human LOXL2 (GenBank Accession No. NM_002318), amino acids 26 – 774 (end) with C-terminal His tag, MW = 85 kDa, expressed in FreeStyle 293-F cells. |
| General description: | Lysyl oxidase like 2 (LOXL2) is part of the LOX family of proteins. It is widely expressed. The gene encoding this protein is localized on human chromosome 8p21.3. It has a conserved carboxy-terminal region with a catalytic function and a divergent amino-terminal region. |
| Legal Information: | FreeStyle is a trademark of Invitrogen Corp. |
| Physical form: | Formulated in 8 mM PBS, pH 7.4, 110 mM NaCl, 2.2 mM KCl, 200 mM imidazole, and 20% glycerol. |
| Symbol |   GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H315 - H319 - H360D |
| Precautionary statements | P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313 |
| Hazard Codes | T |
| Risk Statements | 61 |
| Safety Statements | 53-45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥86% (SDS-PAGE) |
| Storage Temp. | −70°C |
| UNSPSC | 12352202 |